General Information of MIC (ID: MIC01117)
MIC Name	Roseburia hominis (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Roseburia Species: Roseburia hominis
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative; Convert acetate
Gram	Negative
Host Relationship	Commensal
Genome Size (bp)	3592125
Description	Roseburia hominis is a flagellated gut anaerobic bacterium and Gram-positive belonging to the Lachnospiraceae family within the Firmicutes phylum. A significant decrease of R. hominis colonization in the gut of ulcerative colitis patients has recently been demonstrated.
External Links	Taxonomy ID	301301
	Genome Assembly ID	ASM22534v1
	GOLD Organism ID	Go0007768
Disease Relevance
Ulcerative colitis  [ICD-11: DD71]
Description	Roseburia hominis reduced in patients with ulcerative colitis.				[1]

Host Genetic Factors (HGFs)
15q11-13
HGF ID	HGF2318	HGF Info	Class	Copy Number Variation: Gene Duplication (CNV-GDu)
Description	Roseburia hominis was significantly increased in neomycin-treated 15q dup mice (p-value<0.05).				[2]

Host Immune Factors (HIFs)
Neutrophils
HIF ID	HIFC0029	HIF Info	Class	Granulocytes (Gra)
Description	Roseburia hominis at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[3]
Toll like receptor 5 signaling pathway
HIF ID	HIFP0048	HIF Info	Class	Signaling pathway (SP)
Description	Roseburia hominis is associated with TLR5-flagellin signaling.				[4]
CD4+CD25+FOXP3+ regulatory T cells
HIF ID	HIFC0036	HIF Info	Class	T cells (TCs)
Description	Roseburia hominis could increase CD4+CD25+FoxP3+ T cells responses.				[4]

Environmental Factor(s)
Disbiome ID			603
gutMDisorder ID			gm0573

References
1	A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014 Aug;63(8):1275-83. doi: 10.1136/gutjnl-2013-304833. Epub 2013 Sep 10.
2	Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
3	Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
4	Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity. Front Immunol. 2017 Sep 26;8:1166. doi: 10.3389/fimmu.2017.01166. eCollection 2017.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.