Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0048)
HIF Name	Toll like receptor 5 signaling pathway
HIF Synonym(s)	TLR5-flagellin signaling, TLR5 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates NF-B signaling and triggers an innate immune response to the invading pathogen.	[1]

Microbe Species (MIC) Regulated by This HIF
Roseburia hominis (firmicutes)		MIC01117
Description	Roseburia hominis is associated with TLR5-flagellin signaling.		[2]

References
1	Structural basis of TLR5-flagellin recognition and signaling.Science. 2012 Feb 17;335(6070):859-64. doi: 10.1126/science.1215584.
2	Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity. Front Immunol. 2017 Sep 26;8:1166. doi: 10.3389/fimmu.2017.01166. eCollection 2017.

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