Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0036)
HIF Name
CD4+CD25+FOXP3+ regulatory T cells
HIF Synonym(s)
CD4+CD25+Foxp3+ Treg, CD4+CD25+FOXP3+ Tregulatory cells
HIF Classification
T cells (TCs)
Description The most typical Tregs is CD4 + CD25 + Foxp3 + Tregs defined as nTregs (natural Tregs), which is vital to maintain peripheral tolerance and limit beneficial responses. [1]
Microbe Species (MIC) Regulated by This HIF
         Bordetella bronchiseptica (beta-proteobacteria) MIC00245
             Description Bordetella bronchiseptica carriage in the respiratory tract was associated with the expansion of Bordetella-specific CD4+CD25+Foxp3+ Treg. [2]
         Lactobacillus fermentum (firmicutes) MIC00714
             Description Lactobacillus fermentum could increase CD4+CD25+Foxp3+Treg cells responses. [3]
         Parabacteroides distasonis (CFB bacteria) MIC00949
             Description Parabacteroides distasonis induced an increase in CD4+CD25+FoxP3+Treg cells. [4]
         Roseburia hominis (firmicutes) MIC01117
             Description Roseburia hominis could increase CD4+CD25+FoxP3+ T cells responses. [5]
References
1 CD4+CD25+Foxp3+ regulatory T cells suppress NKG2D-mediated NK cell cytotoxicity in peripheral blood. Medicine (Baltimore). 2019 May;98(22):e15722. doi: 10.1097/MD.0000000000015722.
2 Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4+CD25+ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice. Int J Mol Sci. 2018 Sep 1;19(9):2602. doi: 10.3390/ijms19092602.
3 Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota. Gut Microbes. 2019;10(6):696-711. doi: 10.1080/19490976.2019.1589281. Epub 2019 Apr 3.
4 Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol. 2011 Feb;163(2):250-9. doi: 10.1111/j.1365-2249.2010.04286.x. Epub 2010 Nov 19.
5 Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity. Front Immunol. 2017 Sep 26;8:1166. doi: 10.3389/fimmu.2017.01166. eCollection 2017.

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