Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01270)
MIC Name Streptococcus suis (firmicutes)
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus suis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative
Gram Positive
Host Relationship Pathogen
Genome Size (bp) 2094898
No. of Coding Genes 1926
No. of Non-Coding Genes 69
No. of Small Non-Coding Genes 69
No. of Gene Transcripts 1995
No. of Base Pairs 2094898
Description Streptococcus suis is a peanut-shaped, Gram-positive bacterium, and an important pathogen of pigs. Humans can be infected with S. suis when they handle infected pig carcasses or meat, especially with exposed cuts and abrasions on their hands. Human infection can be severe, with meningitis, septicaemia, endocarditis, and deafness as possible outcomes of infection.
External Links Taxonomy ID
1307
Genome Assembly ID
ASM99374v1
GOLD Organism ID
Go0519962
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description Streptococcus suis had a significant difference in the percentage abundance between the EAE-induced CD44 wide type and the CD44 knock out mice (p-value<0.05). [1]
Host Immune Factors (HIFs)
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Streptococcus suis can prevent neutrophil extracellular trap (NET) formation to avoid being trapped by neutrophils. [2]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Streptococcus suis type 2 can disintegrate host immunoglobulins via IgM proteases. [2]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description Streptococcus suis (S. suis) type 2 can prevent neutrophil extracellular trap (NET) formation to avoid being trapped by porcine neutrophils and disintegrate host immunoglobulins via IgA1 hydrolases and IgM proteases. [2]
Environmental Factor(s)
             Disbiome ID
      62
             gutMDisorder ID
      gm0624
             aBiofilm Organism
      Streptococcus suis
References
1 CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
2 How Streptococcus suis serotype 2 attempts to avoid attack by host immune defenses. J Microbiol Immunol Infect. 2019 Aug;52(4):516-525. doi: 10.1016/j.jmii.2019.03.003. Epub 2019 Mar 27.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.