Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0142)
HIF Name
Interferon-21
HIF Synonym(s)
interleukin 21, IL21, Za11, IL-21, CVID11
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description IL21 A gene on chromosome 4q26-q27 that encodes IL-21, a cytokine with immunoregulatory activity that may promote the transition between innate and adaptive immunity. [1]
Pfam Interleukin 15 (PF02372 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Inflammatory bowel disease (IBD) (hsa05321 )
JAK-STAT signaling pathway (hsa04630 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL21_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Clostridium leptum (firmicutes) MIC00402
             Description Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th17 cell responses,which were characterized by IL-21 production. [2]
         Granulicatella adiacens (firmicutes) MIC00645
             Description Granulicatella is positive correlation with IL-21 expression. [3]
References
1 The role of IL-21 in immunity and cancer.Cancer Lett. 2015 Mar 28;358(2):107-114. doi: 10.1016/j.canlet.2014.12.047. Epub 2015 Jan 6.
2 Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
3 The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.

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