Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0147)
HIF Name	Interleukin-2 receptor
HIF Synonym(s)	interleukin 2 receptor subunit alpha, IL2RA, p55, CD25, IL2R, IMD41, TCGFR, IDDM10
HIF Classification	Cytokine (Cyt)
Molecular Function	Receptor
Description	IL-2R was found on the cell surface (either temporary or permanent) in almost all hematopoietic cells including lymphoid linages T, B, and NK cells, as well as myeloid ones like macrophages, monocytes, and neutrophils. The signal is transferred into the cell via the Janus kinasesJak1 and Jak3.		[1]
Pfam	Sushi repeat (SCR repeat) (PF00084 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	Endocytosis (hsa04144 )
	Hematopoietic cell lineage (hsa04640 )
	Human T-cell leukemia virus 1 infection (hsa05166 )
	JAK-STAT signaling pathway (hsa04630 )
	Measles (hsa05162 )
	PI3K-Akt signaling pathway (hsa04151 )
	Pathways in cancer (hsa05200 )
	Th1 and Th2 cell differentiation (hsa04658 )
	Th17 cell differentiation (hsa04659 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
External Links	Uniprot ID	IL2RA_HUMAN

Microbe Species (MIC) Regulated by This HIF
Granulicatella adiacens (firmicutes)		MIC00645
Description	Granulicatella is positive correlation with IL-2R expression.		[2]

References
1	Interleukin-2 receptor signaling: at the interface between tolerance and immunity.Immunity. 2010 Aug 27;33(2):153-65. doi: 10.1016/j.immuni.2010.08.004.
2	The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.

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