| General Information of HGF (ID: HGF1283) |
| HGF Name |
rs1927911
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| Source |
Homo sapiens
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| HGF Classification |
Single Nucleotide Polymorphism: Intron variant (SNP-IV)
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| Gene Location |
chr9:117707776
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| SNP in Gene |
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| Microbe Species (MIC) Regulated by This HGF |
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Chlamydia muridarum (chlamydias)
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MIC00341
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| Description |
The rs1927911 SNP was associated with increased risk of Chlamydia infection in an African American population. |
[1] |
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Escherichia coli (enterobacteria)
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MIC00516
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| Description |
The TLR4 rs1927911 SNP had a significantly decreased risk to become sensitized if they were colonized with Escherichia coli in early infancy. |
[2] |
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Porphyromonas gingivalis (CFB bacteria)
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MIC01000
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| Description |
Combined with Porphyromonas gingivalis infection, rs1927911 (TT/CC+CT) were independent risk factors of chronic periodontitis (p-value=0.004). |
[3] |
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| References |
| 1 |
TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.Pathog Dis. 2016 Feb;74(1):ftv107. doi: 10.1093/femspd/ftv107. Epub 2015 Nov 13.
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| 2 |
Host-microbial interactions in childhood atopy: toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli.J Allergy Clin Immunol. 2010 Jan;125(1):231-6.e1-5. doi: 10.1016/j.jaci.2009.10.011.
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| 3 |
TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals.PeerJ. 2019 Nov 21;7:e7828. doi: 10.7717/peerj.7828. eCollection 2019.
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