General Information of MIC (ID: MIC00341)
MIC Name	Chlamydia muridarum (chlamydias)
MIC Synonyms	Chlamydia trachomatis MoPn
Body Site	Ocular Surface
Lineage	Kingdom: Bacteria Phylum: Chlamydiae Class: Chlamydiia Order: Chlamydiales Family: Chlamydiaceae Genus: Chlamydia Species: Chlamydia muridarum
Oxygen Sensitivity	Aerobe or Anaerobe
Microbial Metabolism	Asaccharolytic
Gram	Negative
Host Relationship	Pathogen
Genome Size (bp)	1072951
No. of Coding Genes	978
No. of Non-Coding Genes	43
No. of Small Non-Coding Genes	43
No. of Gene Transcripts	1021
No. of Base Pairs	1080447
Description	Chlamydia muridarum is a Gram negative, grow under aerobic and anaerobic conditions, rod shaped bacteria. In humans, Chlamydia trachomatis is a common pathogen, with a prevalence of 40 million active ocular infections.
External Links	Taxonomy ID	83560
	Genome Assembly ID	cmvar002
	GOLD Organism ID	Go0499545
Disease Relevance
Acute pharyngitis  [ICD-11: CA02]
Description	Chlamydia muridarum was associated with pharyngitis.				[1]
Bronchitis  [ICD-11: CA20]
Description	Chlamydia muridarum can cause bronchitis.				[1]
Pneumonia  [ICD-11: CA40]
Description	Chlamydia muridarum can cause pneumonitis.				[2]
Prostate inflammatory  [ICD-11: GA91]
Description	Chlamydia muridarum was associated with chronic infection of the prostate.				[3]

Host Genetic Factors (HGFs)
hsa-miR-146a-5p
HGF ID	HGF0252	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-146a-5p was significantly up-regulated during Chlamydia muridarum infection (p-value<0.05).				[4]
rs1927911
HGF ID	HGF1283	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs1927911 SNP was associated with increased risk of Chlamydia infection in an African American population.				[5]

Host Immune Factors (HIFs)
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	Chlamydia muridarum could stimulate IL-1beta secretion.				[6]
THP-1 monocytes
HIF ID	HIFC0214	HIF Info	Class	Monocytes (Mono)
Description	The wild-type (WT) THP-1 cells were infected with Chlamydia muridarum for 24 h, they secreted significantly less IL-1 and activated caspase-1 into the supernatant, confirming that Chlamydia-induced IL-1 secretion relies on caspase-1 activation(p<0.05).				[7]

Environmental Factor(s)
Disbiome ID			508

References
1	Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection. Vaccine. 2006 Jan 16;24(3):355-66. doi: 10.1016/j.vaccine.2005.07.104. Epub 2005 Aug 22.
2	The Genetic Transformation of Chlamydia pneumoniae. mSphere. 2018 Oct 10;3(5):e00412-18. doi: 10.1128/mSphere.00412-18.
3	Chronic Infection of the Prostate by Chlamydia muridarum Is Accompanied by Local Inflammation and Pelvic Pain Development. Prostate. 2017 Apr;77(5):517-529. doi: 10.1002/pros.23291. Epub 2017 Jan 17.
4	Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection. Maudet C, Mano M, Sunkavalli U, Sharan M, Giacca M, Frstner KU, Eulalio A.. Nat Commun. 2014 Aug 22;5:4718. doi: 10.1038/ncomms5718.
5	TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.Pathog Dis. 2016 Feb;74(1):ftv107. doi: 10.1093/femspd/ftv107. Epub 2015 Nov 13.
6	Chlamydia muridarum Infection of Macrophages Stimulates IL-1 Secretion and Cell Death via Activation of Caspase-1 in an RIP3-Independent Manner. Biomed Res Int. 2017;2017:1592365. doi: 10.1155/2017/1592365. Epub 2017 Jun 4.
7	Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.Microbes Infect. 2010 Aug;12(8-9):652-661. doi: 10.1016/j.micinf.2010.04.008. Epub 2010 Apr 29.

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