General Information of HIF (ID: HIFC0214)
HIF Name	THP-1 monocytes
HIF Synonym(s)	THP-1 monocytes
HIF Classification	Monocytes (Mono)
Description	THP-1 monocytes is a type of the immune cells.				[1]

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	Human intestinal mucosa-associated Bifidobacterium strains with probiotic properties modulated gene expression in THP-1 cells.				[2]
Chlamydia muridarum (chlamydias)			MIC00341
Description	The wild-type (WT) THP-1 cells were infected with Chlamydia muridarum for 24 h, they secreted significantly less IL-1 and activated caspase-1 into the supernatant, confirming that Chlamydia-induced IL-1 secretion relies on caspase-1 activation(p<0.05).				[3]
Chlamydia trachomatis (chlamydias)			MIC00344
Description	The wild-type (WT) THP-1 cells were infected with Chlamydia trachomatis for 24 h, they secreted significantly less IL-1 and activated caspase-1 into the supernatant, confirming that Chlamydia-induced IL-1 secretion relies on caspase-1 activation(p<0.05).				[3]
Clostridioides difficile (firmicutes)			MIC00396
Description	THP-1 monocytes response were associated with pathogenic inflammation caused by Clostridium difficile infection.				[4]
Lactobacillus paracasei (firmicutes)			MIC00726
Description	THP-1 monocytes enzymatic activity were activated by a Rhamnose-rich hetero-exopolysaccharide isolated from Lactobacillus paracasei.				[5]

References
1	A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.PLoS One. 2016 Mar 3;11(3):e0150606. doi: 10.1371/journal.pone.0150606. eCollection 2016.
2	Human intestinal mucosa-associated Lactobacillus and Bifidobacterium strains with probiotic properties modulate IL-10, IL-6 and IL-12 gene expression in THP-1 cells. Benef Microbes. 2015;6(3):325-36. doi: 10.3920/BM2014.0081.
3	Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.Microbes Infect. 2010 Aug;12(8-9):652-661. doi: 10.1016/j.micinf.2010.04.008. Epub 2010 Apr 29.
4	Bile acid analogues are activators of pyrin inflammasome.J Biol Chem. 2019 Mar 8;294(10):3359-3366. doi: 10.1074/jbc.RA118.005103. Epub 2019 Jan 15.
5	A Novel Rhamnose-Rich Hetero-exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells.Appl Environ Microbiol. 2017 Jan 17;83(3):e02702-16. doi: 10.1128/AEM.02702-16. Print 2017 Feb 1.

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