Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01385)
MIC Name Weissella confusa (firmicutes)
MIC Synonyms Lactobacillus coprophilus subsp. confusus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Leuconostocaceae
Genus: Weissella
Species: Weissella confusa
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative; Respiratory
Gram Negative
Genome Size (bp) 2218304
No. of Coding Genes 1998
No. of Gene Transcripts 1998
No. of Base Pairs 2218304
Description Weissella confusa, known as Lactobacillus confusus, is a facultative anaerobic, Gram negative bacterium. This bacterium can cause bacteraemia in immunocompromised hosts.
External Links Taxonomy ID
1583
Genome Assembly ID
ASM143689v1
GOLD Organism ID
Go0017790
Disease Relevance
          Meningococcal disease  [ICD-11: 1C1C]
             Description Weissella confusa should be included in the list of organisms causing bacteraemia in immunocompromised hosts. [1]
Host Genetic Factors (HGFs)
          rs3775467
             HGF ID HGF1507 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3775467 SNP was significantly associated with the relative abundance of Weissella (p-value=2.44E-09). [2]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Weissella spp.were selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). [3]
Environmental Factor(s)
             Disbiome ID
      873
             gutMDisorder ID
      gm0689
References
1 Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997-2007. Clin Microbiol Infect. 2011 Aug;17(8):1226-31. doi: 10.1111/j.1469-0691.2010.03388.x. Epub 2010 Dec 6.
2 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
3 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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