General Information of MIC (ID: MIC00734)
MIC Name	Lactobacillus sakei (firmicutes)
MIC Synonyms	Lactobacillus sake
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus sakei
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Respiratory or Fermentative
Gram	Positive
Host Relationship	Probiotic
Genome Size (bp)	2185902
No. of Coding Genes	1869
No. of Non-Coding Genes	67
No. of Small Non-Coding Genes	67
No. of Gene Transcripts	1936
No. of Base Pairs	2185902
Description	Lactobacillus sakei is a facultatively anaerobic, Gram-positive bacterium.
External Links	Taxonomy ID	1599
	Genome Assembly ID	ASM75562v1
	GOLD Organism ID	Go0000424
Disease Relevance
Vibrio mimicus gastroenteritis  [ICD-11: 1A40]
Description	Lactobacillus sakei genetically modified with pprI gene should be developed as a favorable option for the prevention and treatment of radiation-induced enteritis.				[1]

Host Immune Factors (HIFs)
Immunoglobulin A
HIF ID	HIFM0272	HIF Info	Class	Immunoglobulin (Ig)
Description	MVs released from Lactobacillus sakei NBRC15893 could enhance IgA production.				[2]
Toll like receptor 2 signalling pathway
HIF ID	HIFP0044	HIF Info	Class	Signaling pathway (SP)
Description	MVs released from Lactobacillus sakei NBRC15893 enhance IgA production by activating host TLR2 signaling through its cell wall components.				[2]

Environmental Factor(s)
Disbiome ID			487
gutMDisorder ID			gm0393

References
1	Use of recombinant Lactobacillus sakei for the prevention and treatment of radiation-induced enteritis. Med Hypotheses. 2018 Oct;119:37-40. doi: 10.1016/j.mehy.2018.07.024. Epub 2018 Jul 29.
2	IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893. Biosci Microbiota Food Health. 2019;38(1):23-29. doi: 10.12938/bmfh.18-015. Epub 2018 Nov 1.

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