Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00547)
MIC Name Enterococcus durans (firmicutes)
MIC Synonyms Streptococcus durans
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus durans
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 3170474
Description Enterococcus durans is a facultative anaerobic, Gram-positive, catalase- and oxidase-negative, coccus bacterium of Enterococcus. Enterococcus durans is a very rare, low-virulence species of enterococcus.
External Links Taxonomy ID
53345
Genome Assembly ID
Ente_dura_ATCC6056_V1
GOLD Organism ID
Go0020480
Disease Relevance
          Chronic liver disease  [ICD-11: DB99]
             Description Enterococcus durans may cause a fatal outcome in a patient with advanced liver disease in spite of optimised antibiotic therapy. [1]
          Infectious endocarditis  [ICD-11: BB40]
             Description Endocardial infection was associated with Enterococcus durans infection. [1]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Enterococcus durans can increase IL-10 secretion in response to LPS stimulation. [2]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Enterococcus durans stimulates PBMC to increase secretion of cytokines IL-1. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The effect of Enterococcus durans EP1 administration on ileum gene expression: a decrease in mRNA amounts of the proinflammatory molecules IL6, IL1b, IL12p70, and tnf-alpha after 7 days. [2]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Enterococcus durans EP1 Administration Increases sIgA in Feces. [2]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Enterococcus durans presented a profile toward a mild inflammatory Th1 response. [2]
Environmental Factor(s)
             Disbiome ID
      1146
             gutMDisorder ID
      gm0287
References
1 Fatal Enterococcus durans aortic valve endocarditis: a case report and review of the literature. BMJ Case Rep. 2012 Jun 8;2012:bcr0220125855. doi: 10.1136/bcr-02-2012-5855.
2 Enterococcus durans EP1 a Promising Anti-inflammatory Probiotic Able to Stimulate sIgA and to Increase Faecalibacterium prausnitzii Abundance. Front Immunol. 2017 Feb 10;8:88. doi: 10.3389/fimmu.2017.00088. eCollection 2017.

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