Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00008)
MIC Name Acidaminococcus fermentans (firmicutes)
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Acidaminococcales
Family: Acidaminococcaceae
Genus: Acidaminococcus
Species: Acidaminococcus fermentans
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Fermentative; Utilize amino acids as the energy source
Gram Negative
Genome Size (bp) 2329769
Description Acidaminococcus fermentans belongs to the group of strictly anaerobic gram-negative cocci.
External Links Taxonomy ID
905
Genome Assembly ID
ASM2530v1
GOLD Organism ID
Go0001186
Disease Relevance
          Spondyloarthritis  [ICD-11: FA92]
             Description Acidaminococcus fermentans was associated with ankylosing spondylitis. [1]
Host Genetic Factors (HGFs)
          rs7899016
             HGF ID HGF1534 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7899016 SNP was significantly associated with the relative abundance of Acidaminococcus (p-value=4.97E-12). [2]
          rs62273067
             HGF ID HGF1459 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs62273067 SNP was significantly associated with the relative abundance of Acidaminococcus (p-value=9.40E-10). [2]
          rs41269155
             HGF ID HGF1323 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs41269155 SNP was significantly associated with the relative abundance of Acidaminococcus (p-value=2.57E-12). [2]
          rs17739409
             HGF ID HGF1999 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17739409 SNP was significantly associated with the relative abundance of Acidaminococcus (p-value=1.14E-09). [2]
          rs1450758
             HGF ID HGF1992 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1450758 SNP was significantly associated with the relative abundance of Acidaminococcus (p-value=5.55E-16). [2]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Acidaminococcus spp. were selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis). [3]
Environmental Factor(s)
             Disbiome ID
      399
             gutMDisorder ID
      gm0006
References
1 Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis. J Autoimmun. 2020 Feb;107:102360. doi: 10.1016/j.jaut.2019.102360. Epub 2019 Dec 2.
2 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
3 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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