Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01441)
MIC Name Anaerostipes hadrus (firmicutes)
MIC Synonyms Eubacterium hadrum
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Anaerostipes
Species: Anaerostipes hadrus
Gram Positive
Genome Size (bp) 3114788
No. of Coding Genes 2771
No. of Non-Coding Genes 118
No. of Small Non-Coding Genes 118
No. of Gene Transcripts 2889
No. of Base Pairs 3114788
Description Anaerostipes hadrus is a Gram-positive bacterium from the genus of Anaerostipes which has been isolated from human faeces
External Links Taxonomy ID
649756
Genome Assembly ID
ASM21069v1
GOLD Organism ID
Go0003539
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Anaerostipes was associated with inflammatory bowel disease. [1]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Anaerostipes was associated with irritable bowel syndrome. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Anaerostipes differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [2]
          rs571312
             HGF ID HGF2159 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Anaerostipes (p-value<0.0001). [3]
          rs2630788
             HGF ID HGF1231 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2630788 SNP was significantly associated with the abundance of Anaerostipes (p-value=4.90E-08). [4]
          rs10233359
             HGF ID HGF2008 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10233359 SNP was significantly associated with the abundance of gut microbiota Anaerostipes (p-value<5.00E-05). [5]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Anaerostipes was significantly enriched in the IgA (Low or no IgA binding) consortia. [6]
Environmental Factor(s)
             Disbiome ID
      7
             gutMDisorder ID
      gm0052
References
1 Fecal and Mucosal Microbiota Profiling in Irritable Bowel Syndrome and Inflammatory Bowel Disease. Front Microbiol. 2019 Jul 17;10:1655. doi: 10.3389/fmicb.2019.01655. eCollection 2019.
2 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
3 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
5 Assessing the Relationship Between Gut Microbiota and Bone Mineral Density.Front Genet. 2020 Jan 31;11:6. doi: 10.3389/fgene.2020.00006. eCollection 2020.
6 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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