Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01291)
MIC Name Sutterella parvirubra (beta-proteobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Sutterellaceae
Genus: Sutterella
Species: Sutterella parvirubra
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative; Respiratory
Gram Negative
Genome Size (bp) 2374505
Description Sutterella parvirubra is a Gram-negative, oxidase- and catalase-negative, anaerobic, non-spore-forming, nonmotile bacterium from the genus Sutterella in the family Sutterellaceae, which was isolated from human faeces.
External Links Taxonomy ID
437898
Genome Assembly ID
ASM25087v1
GOLD Organism ID
Go0006421
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Sutterella was observed in abundance and may be involved in the pathogenesis of Autism Spectrum Disorder. [1]
          Crohn disease  [ICD-11: DD70]
             Description Sutterella was decreased in Crohns disease patients. [2]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Sutterella parvirubra was associated with inflammatory bowel disease. [3]
Host Genetic Factors (HGFs)
          ARNTL
             HGF ID HGF2325 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of BMAL1 could decrease relative abundances of Sutterella (p-value<0.0001). [4]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Sutterella differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [5]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could increase the abundance of Sutterella. [6]
          rs651821
             HGF ID HGF1925 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The APOA5 rs651821 SNP increased the abundance of Sutterella. [7]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Sutterella was significantly enriched in the IgA (Low or no IgA binding) consortia. [8]
Environmental Factor(s)
             Disbiome ID
      175
             gutMDisorder ID
      gm0631
References
1 Gut Microbiota and Autism: Key Concepts and Findings. J Autism Dev Disord. 2017 Feb;47(2):480-489. doi: 10.1007/s10803-016-2960-9.
2 Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection. Genome Med. 2016 Apr 28;8(1):49. doi: 10.1186/s13073-016-0301-4.
3 Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp. Front Microbiol. 2016 Oct 26;7:1706. doi: 10.3389/fmicb.2016.01706. eCollection 2016.
4 Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3.
5 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
6 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
7 The effect of host genetics on the gut microbiome.Nat Genet. 2016 Nov;48(11):1407-1412. doi: 10.1038/ng.3663. Epub 2016 Oct 3.
8 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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