Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01364)
MIC Name Veillonella dispar (firmicutes)
MIC Synonyms Veillonella alcalescens subsp. dispar
Body Site Mucosa
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Veillonella
Species: Veillonella dispar
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2040890
No. of Coding Genes 1945
No. of Non-Coding Genes 40
No. of Small Non-Coding Genes 40
No. of Gene Transcripts 1985
No. of Base Pairs 2040890
Description Veillonella dispar is an obligately anaerobic, Gram negative bacteria. It is emerging as a pathogen.
External Links Taxonomy ID
39778
Genome Assembly ID
ASM155331v1
GOLD Organism ID
Go0003909
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Veillonella dispar was associated with primary sclerosing cholangitis. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Veillonella dispar is upregulated in inflammatory bowel disease. [1]
Host Genetic Factors (HGFs)
          rs7629566
             HGF ID HGF1421 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs7629566 SNP was significantly associated with the abundance of Veillonella dispar (p-value<1.00E-08). [2]
          rs347941
             HGF ID HGF1769 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs347941 SNP was significantly associated with the abundance of Veillonella dispar (p-value=2.31E-07). [3]
          rs1497840
             HGF ID HGF1669 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1497840 SNP was significantly associated with the abundance of Veillonella dispar (p-value<1.00E-08). [2]
          rs2945412
             HGF ID HGF2655 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2945412 SNP is associated with the abundance of Veillonella dispar. [4]
          rs26528
             HGF ID HGF2656 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs26528 SNP is associated with the abundance of Veillonella dispar. [4]
          rs11879191
             HGF ID HGF2623 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11879191 SNP is associated with the abundance of Veillonella dispar. [4]
          rs7495132
             HGF ID HGF2631 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7495132 SNP is associated with the abundance of Veillonella dispar. [4]
          rs3091315
             HGF ID HGF2612 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3091315 SNP is associated with the abundance of Veillonella dispar. [4]
          rs7134599
             HGF ID HGF2634 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7134599 SNP is associated with the abundance of Veillonella dispar. [4]
          rs4976646
             HGF ID HGF2657 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4976646 SNP is associated with the abundance of Veillonella dispar. [4]
          rs28374715
             HGF ID HGF2658 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs28374715 SNP is associated with the abundance of Veillonella dispar. [4]
          rs13204742
             HGF ID HGF2560 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs13204742 SNP is associated with the abundance of Veillonella dispar. [4]
          rs11150589
             HGF ID HGF2659 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The rs11150589 SNP is associated with the abundance of Veillonella dispar. [4]
          rs17391694
             HGF ID HGF2641 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17391694 SNP is associated with the abundance of Veillonella dispar. [4]
          rs1654644
             HGF ID HGF2660 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1654644 SNP is associated with the abundance of Veillonella dispar. [4]
          rs13407913
             HGF ID HGF2607 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13407913 SNP is associated with the abundance of Veillonella dispar. [4]
          rs9264942
             HGF ID HGF2579 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9264942 SNP is associated with the abundance of Veillonella dispar. [4]
          rs568617
             HGF ID HGF2648 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs568617 SNP is associated with the abundance of Veillonella dispar. [4]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Veillonella dispar was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). [5]
Environmental Factor(s)
             Disbiome ID
      401
             gutMDisorder ID
      gm0677
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
4 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
5 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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