Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00653)
MIC Name Haemophilus parainfluenzae (gamma-proteobacteria)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Haemophilus
Species: Haemophilus parainfluenzae
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 2086875
No. of Coding Genes 1818
No. of Non-Coding Genes 54
No. of Small Non-Coding Genes 54
No. of Gene Transcripts 1872
No. of Base Pairs 1978346
Description Haemophilus parainfluenzae is a specie of aerobic, Gram negative bacteria in the genus Haemophilus. It is an opportunistic pathogen that has been associated with endocarditis, bronchitis, otitis, conjunctivitis, pneumonia, abscesses and genital tract infections.
External Links Taxonomy ID
729
Genome Assembly ID
ASM127914v1
GOLD Organism ID
Go0001515
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Haemophilus parainfluenzae were lower in feces of children with autism spectrum disorder. [1]
          Behcet disease  [ICD-11: 4A62]
             Description Haemophilus parainfluenzae was the most overabundant species in Behcet's disease. [2]
          Bronchitis  [ICD-11: CA20]
             Description Haemophilus parainfluenzae was associated with chronic bronchitis. [3]
          Conjunctivitis  [ICD-11: 9A60]
             Description Hemophilus parainfluenzae, a common upper respiratory tract pathogen, has been reported to cause pharyngitis, epiglottitis, otitis media, conjunctivitis, and pneumonia. [4]
          Infectious endocarditis  [ICD-11: BB40]
             Description An aggressive form of Haemophilus parainfluenzae infective endocarditis presenting with limb weakness. [5]
          Otitis  [ICD-11: AA02]
             Description Haemophilus parainfluenzae is a nutritionally fastidious, Gram-negative bacterium with an oropharyngeal/nasopharyngeal carriage niche that is associated with otitis media. [6]
          Pneumonia  [ICD-11: CA40]
             Description Haemophilus parainfluenzae had a pathogenic role in the patient's pneumonia. [7]
          Skin abscesses  [ICD-11: 1B75]
             Description Haemophilus parainfluenzae can cause abscess. [8]
Host Genetic Factors (HGFs)
          rs11742570
             HGF ID HGF2603 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11742570 SNP is associated with the abundance of Haemophilus parainfluenzae. [9]
          rs3742130
             HGF ID HGF2570 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs3742130 SNP is associated with the abundance of Haemophilus parainfluenzae. [9]
          rs561722
             HGF ID HGF2632 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs561722 SNP is associated with the abundance of Haemophilus parainfluenzae. [9]
          rs7097656
             HGF ID HGF2572 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7097656 SNP is associated with the abundance of Haemophilus parainfluenzae. [9]
          rs3764147
             HGF ID HGF2633 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs3764147 SNP is associated with the abundance of Haemophilus parainfluenzae. [9]
          rs7134599
             HGF ID HGF2634 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7134599 SNP is associated with the abundance of Haemophilus parainfluenzae. [9]
Host Immune Factors (HIFs)
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Haemophilus parainfluenzae was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). [10]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description Lymphocytes from patients with IgAN also showed a significantly higher level of IgA antibody and IgA1 antibody against Haemophilus parainfluenzae(HPI) antigens in culture supernatants than lymphocytes from controls (P = 0.0002 and P = 0.004, respectively). [11]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Haemophilus parainfluenzae induced production of IgA1 in tonsillar lymphocytes from IgA nephropathy. [11]
Environmental Factor(s)
             Disbiome ID
      56
             gutMDisorder ID
      gm0358
References
1 Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. Anaerobe. 2018 Feb;49:121-131. doi: 10.1016/j.anaerobe.2017.12.007. Epub 2017 Dec 22.
2 Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behet's disease. Clin Immunol. 2016 Aug;169:28-35. doi: 10.1016/j.clim.2016.06.002. Epub 2016 Jun 7.
3 Biotypes of Haemophilus parainfluenzae from the respiratory secretions in chronic bronchitis. J Med Microbiol. 1992 Apr;36(4):279-82. doi: 10.1099/00222615-36-4-279.
4 Hemophilus parainfluenzae prostatitis in a homosexual man with chronic lymphadenopathy syndrome and HTLV-III infection. Am J Med. 1987 Jan;82(1):175-8. doi: 10.1016/0002-9343(87)90403-7.
5 An aggressive form of Haemophilus parainfluenzae infective endocarditis presenting with limb weakness. BMJ Case Rep. 2018 Jun 4;2018:bcr2017223775. doi: 10.1136/bcr-2017-223775.
6 Haemophilus parainfluenzae Strain ATCC 33392 Forms Biofilms In Vitro and during Experimental Otitis Media Infections. Infect Immun. 2017 Aug 18;85(9):e01070-16. doi: 10.1128/IAI.01070-16. Print 2017 Sep.
7 A case of Haemophilus parainfluenzae pneumonia. Thorax. 2000 Jul;55(7):623-4. doi: 10.1136/thorax.55.7.623.
8 [Epiglottitis with an abscess caused by Haemophilus parainfluenzae]. Ugeskr Laeger. 2014 Mar 17;176(12A):V11130683.
9 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
10 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.
11 Immune response of tonsillar lymphocytes to Haemophilus parainfluenzae in patients with IgA nephropathy. Clin Exp Immunol. 2000 Feb;119(2):328-32. doi: 10.1046/j.1365-2249.2000.01143.x.

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