General Information of MIC (ID: MIC00042)
MIC Name	Adlercreutzia equolifaciens (actinobacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Coriobacteriia Order: Eggerthellales Family: Eggerthellaceae Genus: Adlercreutzia Species: Adlercreutzia equolifaciens
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Asaccharolytic; Nonfermentative
Gram	Positive
Host Relationship	Commensal
Genome Size (bp)	2862526
Description	Adlercreutzia equolifaciens is a obligate anaerobic, Gram positive bacterium isolated from human faeces.
External Links	Taxonomy ID	446660
	Genome Assembly ID	ASM47888v1
	GOLD Organism ID	Go0030564
Disease Relevance
Autoimmune liver disease  [ICD-11: DB96]
Description	Adlercreutzia equolifaciens is downregulated in disease expression				[1]

Host Genetic Factors (HGFs)
15q11-13
HGF ID	HGF2318	HGF Info	Class	Copy Number Variation: Gene Duplication (CNV-GDu)
Description	The duplicaton of 15q is assciated with the reduction of the relative abundance of Adlercreutzia caused by ampicillin (p-value<0.05).				[2]
NOD2
HGF ID	HGF2335	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of NOD2 showed significantly increased abundance of Adlercreutzia equolifaciens (p-value<0.05).				[3]
SLC15A1
HGF ID	HGF2354	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of PepT1 could decrease the abundance of Adlercreutzia.				[4]

Host Immune Factors (HIFs)
Immunoglobulin A
HIF ID	HIFM0272	HIF Info	Class	Immunoglobulin (Ig)
Description	Adlercreutzia was significantly enriched in the IgA(Low or no IgA binding) consortia.				[5]

Environmental Factor(s)
Disbiome ID			932
gutMDisorder ID			gm0022

References
1	Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2	Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
3	Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.Sci Rep. 2017 Apr 3;7(1):548. doi: 10.1038/s41598-017-00484-2.
4	Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
5	IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.