Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0007)
HIF Name	Extracellular signal-regulated kinase signaling pathway
HIF Synonym(s)	ERK, ERK signaling pathway
HIF Classification	Signaling pathway (SP)
Description	The extracellular-signal-regulated kinase (ERK) pathway is one of the major signaling cassettes of the mitogen activated protein kinase (MAPK) signaling pathway.	[1]

Microbe Species (MIC) Regulated by This HIF
Klebsiella pneumoniae (enterobacteria)		MIC01405
Description	At the species level, Klebsiella pneumoniae is associated with ERK.		[2]

References
1	The expression of ER, PR in endometrial cancer and analysis of their correlation with ERK signaling pathway.Cancer Biomark. 2017 Dec 12;21(1):145-149. doi: 10.3233/CBM-170457.
2	Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.

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