General Information of HIF (ID: HIFC0032)
HIF Name	Type 1 regulatory T cells
HIF Synonym(s)	Tr1, Type 1 Tregulatory cells
HIF Classification	T cells (TCs)
Description	Type 1 regulatory T (Tr1) cells are an inducible subset of regulatory T cells that play a pivotal role in promoting and maintaining tolerance. The main mechanisms by which Tr1 cells control immune responses are the secretion of high levels of IL-10, and the killing of myeloid myeloid cells through the release of Granzyme B.				[1]

Microbe Species (MIC) Regulated by This HIF
Lactobacillus pentosus (firmicutes)			MIC00728
Description	Lactobacillus pentosus modulated immune response by inducing Il-10 producing Tr1 cells(Type 1 regulatory T cells).				[2]

References
1	The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.Immunity. 2018 Dec 18;49(6):1004-1019. doi: 10.1016/j.immuni.2018.12.001.
2	Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells. Immune Netw. 2019 Dec 26;19(6):e39. doi: 10.4110/in.2019.19.e39. eCollection 2019 Dec.

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