General Information of HIF (ID: HIFC0086)
HIF Name	T helper type 9 cells
HIF Synonym(s)	Th9, T helper type 9(Th9) cells
HIF Classification	T cells (TCs)
Description	Th9 cells (T helper type 9 cells, CD4+IL-9+IL-13 IFN ) are a sub-population of CD4+T cells that produce interleukin-9 (IL-9). They play a role in defense against helminth infections, in allergic responses, in autoimmunity, and tumor suppression.				[1]

Microbe Species (MIC) Regulated by This HIF
Clostridium leptum (firmicutes)			MIC00402
Description	Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung, resulting in the inhibition of Th9 cell responses.				[2]

References
1	Th9 Cells in Allergic Disease.Curr Allergy Asthma Rep. 2019 Mar 26;19(5):29. doi: 10.1007/s11882-019-0860-8.
2	Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.

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