Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0002)
HIF Name
Adenosine receptor A2a
HIF Synonym(s)
ADORA2A, Adenosine A2A Receptor, A2aR
HIF Classification
Checkpoint molecule (CM)
Molecular Function
G-protein coupled receptor; Receptor; Transducer
Description Adenosine receptor A2a is a G-protein-coupled receptor that is a major target of caffeine and important for regulating myocardial oxygen consumption, coronary blood flow, and CNS neurotransmitters, thus a receptor of interest for new drug development. [1]
Pfam 7 transmembrane receptor (rhodopsin family) (PF00001 )
Pathway Alcoholism (hsa05034 )
Calcium signaling pathway (hsa04020 )
Neuroactive ligand-receptor interaction (hsa04080 )
Parkinson disease (hsa05012 )
Rap1 signaling pathway (hsa04015 )
Vascular smooth muscle contraction (hsa04270 )
cAMP signaling pathway (hsa04024 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
AA2AR_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Clostridioides difficile (firmicutes) MIC00396
             Description Toxin A (TxA) release from Clostridium difficile can contribute to antibiotic-induced diarrhea and pseudomembranous colitis through A2aRs. [2]
         Lactobacillus reuteri (firmicutes) MIC00731
             Description A2aR receptors, which were required for the efficacy of inosine and of Lactobacillus reuteri in vivo. [3]
References
1 Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.Cancer Immunol Immunother. 2018 Aug;67(8):1271-1284. doi: 10.1007/s00262-018-2186-0. Epub 2018 Jun 19.
2 New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC.Inflamm Bowel Dis. 2009 Jul;15(7):971-84. doi: 10.1002/ibd.20893.
3 Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.J Exp Med. 2017 Jan;214(1):107-123. doi: 10.1084/jem.20160961. Epub 2016 Dec 19.

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