Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0008)
HIF Name
Bactericidal permeability-increasing protein
HIF Synonym(s)
BPI, CAP 57
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial
Description Bactericidal/permeability-increasing protein (BPI) human LEAP-1 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam LBP / BPI / CETP family, C-terminal domain (PF02886 )
LBP / BPI / CETP family, N-terminal domain (PF01273 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
BPI_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Micrococcus luteus (actinobacteria) MIC00824
             Description Micrococcus luteus demonstrated that transcription of BPI increases in the larval stage in a bacterial-dose dependent manner. [2]
References
1 Antimicrobial peptides and the skin immune defense system.J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2 LBP/BPI proteins and their relatives: conservation over evolution and roles in mutualism.Biochem Soc Trans. 2011 Aug;39(4):1039-44. doi: 10.1042/BST0391039.

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