General Information of HIF (ID: HIFM0016)
HIF Name	C-C motif chemokine 1
HIF Synonym(s)	Ccl1, I-309
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	CCL1 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL1_HUMAN
	APD ID	AP02089

Microbe Species (MIC) Regulated by This HIF
Enterococcus faecium (firmicutes)			MIC00549
Description	Enterococcus faecalis oral infection has been completely improved after elimination of M2b phenotype by CCL1 antisense oligodeoxynucleotide (ODN).				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation.J Immunol. 2018 Jul 1;201(1):77-86. doi: 10.4049/jimmunol.1701515. Epub 2018 May 9.

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