General Information of HIF (ID: HIFM0026)
HIF Name	C-C motif chemokine 24
HIF Synonym(s)	Eotaxin-2, CCL-24, Eotaxin-2
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	Eotaxin-2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL24_HUMAN
	APD ID	AP02454

Microbe Species (MIC) Regulated by This HIF
Anaerococcus vaginalis (firmicutes)			MIC00079
Description	The reduction in Anaerococcus abundance in eosinophilic CRSwNPs patients was associated with the CCL24(Eotaxin-2) levels in tissues.				[2]
Lachnoclostridium (firmicutes)			MIC01882
Description	The observation that IL-5-producing ILC2 populations correlated with the mediators of eosinophilic inflammation CCL24(Eotaxin-2) levels in tissues, might explain the RA of Lachnoclostridium in eosinophilic CRSwNPs patients.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps.Exp Mol Med. 2020 Jun;52(6):978-987. doi: 10.1038/s12276-020-0458-1. Epub 2020 Jun 29.

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