General Information of MIC (ID: MIC01882)
MIC Name	Lachnoclostridium (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Lachnoclostridium
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Description	Lachnoclostridium, a newly proposed genus within the family Lachnospiraceae, a group of Gram-positive, motile, obligately anaerobic spore-forming and rod-shape Clostridia, are able to ferment mono- and disaccharides mainly producing acetate.
External Links	Taxonomy ID	1506553
	GOLD Organism ID	Go0545334

Host Genetic Factors (HGFs)
NOD2
HGF ID	HGF2335	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of NOD2 showed significantly increased abundance of Lachnoclostridium (p-value<0.05).				[1]

Host Immune Factors (HIFs)
C-C motif chemokine 24
HIF ID	HIFM0026	HIF Info	Class	Antimicrobial peptide (AMP)
Description	The observation that IL-5-producing ILC2 populations correlated with the mediators of eosinophilic inflammation CCL24(Eotaxin-2) levels in tissues, might explain the RA of Lachnoclostridium in eosinophilic CRSwNPs patients.				[2]
C-C motif chemokine 11
HIF ID	HIFM0017	HIF Info	Class	Cytokine (Cyt)
Description	There were significant correlations between the levels of other cytokines and chemokines CCL11 and the abundance of Lachnoclostridium(p>0.05).				[2]

Environmental Factor(s)
Disbiome ID			636

References
1	Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.Sci Rep. 2017 Apr 3;7(1):548. doi: 10.1038/s41598-017-00484-2.
2	Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps.Exp Mol Med. 2020 Jun;52(6):978-987. doi: 10.1038/s12276-020-0458-1. Epub 2020 Jun 29.

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