General Information of HIF (ID: HIFM0017)
HIF Name	C-C motif chemokine 11
HIF Synonym(s)	C-C motif chemokine ligand 11, SCYA11
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine
Description	Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Asthma (hsa05310 )
	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	IL-17 signaling pathway (hsa04657 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL11_HUMAN

Microbe Species (MIC) Regulated by This HIF
Anaerococcus vaginalis (firmicutes)			MIC00079
Description	There was significant correlations between the levels of cytokines CCL11 and the abundance of Anaerococcus(p>0.05).				[2]
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	Oral administration of Bifidobacterium blocked pro-inflammatory cytokines CCL11 expression in the gut.				[3]
Enterococcus faecalis (firmicutes)			MIC00548
Description	Enterococcus faecalis is associated with the CCL11 activation.				[4]
Lachnoclostridium (firmicutes)			MIC01882
Description	There were significant correlations between the levels of other cytokines and chemokines CCL11 and the abundance of Lachnoclostridium(p>0.05).				[2]

References
1	Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation.Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201600868. Epub 2017 Apr 27.
2	Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps.Exp Mol Med. 2020 Jun;52(6):978-987. doi: 10.1038/s12276-020-0458-1. Epub 2020 Jun 29.
3	Not Avaliable
4	Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection. J Infect Dis. 2017 Dec 19;216(12):1644-1654. doi: 10.1093/infdis/jix541.

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