General Information of HIF (ID: HIFM0030)
HIF Name	C-C motif chemokine 28
HIF Synonym(s)	Ccl28, MEC
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	CCL28 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Intestinal immune network for IgA production (hsa04672 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CCL28_HUMAN
	APD ID	AP02192

Microbe Species (MIC) Regulated by This HIF
Bacillus cereus (firmicutes)			MIC00122
Description	CCL28 killed Bacillus cereus, which belong to Class Bacilli, with a half-maximum killing concentration of 2.16 0.2 mM.				[2]
Enterococcus faecalis (firmicutes)			MIC00548
Description	CCL28 killed Enterococcus faecalis, which belong to Class Bacilli, with a half-maximum killing concentration of 4.06 0.2 mM.				[2]
Salmonella sp. (enterobacteria)			MIC01149
Description	CCL28 plays a major role in innate immunity against Salmonella enzymatic activity in the gut.				[3]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	CCL28-Deficient Mice Have Reduced IgA Antibody-Secreting Cells and an Altered Microbiota in the Colon.J Immunol. 2018 Jan 15;200(2):800-809. doi: 10.4049/jimmunol.1700037. Epub 2017 Dec 13.
3	CCL28 Is Involved in Mucosal IgA Responses, Olfaction, and Resistance to Enteric Infections.J Interferon Cytokine Res. 2019 Apr;39(4):214-223. doi: 10.1089/jir.2018.0099. Epub 2019 Mar 11.

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