Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0032)
HIF Name
Macrophage inflammatory protein 1-beta
HIF Synonym(s)
MIP3, Macrophage inflammatory protein 3
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Macrophage inflammatory protein 1 beta (MIP-1), also known as Chemokine (C-C motif) ligand 4 (CCL4), is a small cytokine belonging to the CC chemokine family. It is a chemo attractant for natural killer cells, monocytes and a variety of other immune cell [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Cytosolic DNA-sensing pathway (hsa04623 )
Human cytomegalovirus infection (hsa05163 )
NF-kappa B signaling pathway (hsa04064 )
Toll-like receptor signaling pathway (hsa04620 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CCL4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bifidobacterium pseudocatenulatum (actinobacteria) MIC00219
             Description Bifidobacterium pseudocatenulatum could decrease the MIP-3Alpha expression. [2]
         Klebsiella aerogenes (enterobacteria) MIC00530
             Description Enterobacter aerogenes is associated with the MIP-1Beta expression. [3]
References
1 High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism.Nephrol Dial Transplant. 2007 Nov;22(11):3147-53. doi: 10.1093/ndt/gfm365. Epub 2007 Jul 29.
2 Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota. Sci Rep. 2017 Aug 18;7(1):8770. doi: 10.1038/s41598-017-09395-8.
3 Immunological cross-reactivity between Enterobacter aerogenes and Klebsiella capsular polysaccharides. Microb Pathog. 1990 Aug;9(2):127-30. doi: 10.1016/0882-4010(90)90086-6.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.