Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0052)
HIF Name
Antigenic surface determinant protein OA3
HIF Synonym(s)
IAP, Protein MER6, CD47
HIF Classification
Checkpoint molecule (CM)
Description CD47 is a marker-of-self protein that is overexpressed broadly across tumor types, is emerging as a novel potent macrophage immune checkpoint for cancer immunotherapy. [1]
Pfam CD47 immunoglobulin-like domain (PF08204 )
CD47 transmembrane region (PF04549 )
Pathway ECM-receptor interaction (hsa04512 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD47_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bifidobacterium sp. (actinobacteria) MIC00224
             Description Local delivery of Bifidobacterium potently stimulates STING signaling and increases cross-priming of dendritic cells after anti-CD47 treatment. [2]
References
1 CD47: the next checkpoint target for cancer immunotherapy.Crit Rev Oncol Hematol. 2020 Aug;152:103014. doi: 10.1016/j.critrevonc.2020.103014. Epub 2020 Jun 2.
2 Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.J Exp Med. 2020 May 4;217(5):e20192282. doi: 10.1084/jem.20192282.

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