Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0056)
HIF Name
T-cell surface glycoprotein CD8 alpha chain
HIF Synonym(s)
CD8a molecule, CD8A, p32, Leu2
HIF Classification
T-cell receptor (TCR)
Description As a component of the immune system, CD8(+) T cells have important roles in suppressing tumors. CD8(+) T cells can kill tumor cells with cytotoxic molecules, such as granzymes and perforin. [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Pathway Antigen processing and presentation (hsa04612 )
Cell adhesion molecules (CAMs) (hsa04514 )
Hematopoietic cell lineage (hsa04640 )
Primary immunodeficiency (hsa05340 )
T cell receptor signaling pathway (hsa04660 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD8A_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description A purified membrane protein from Akkermansia muciniphila can modulate CD8+ T cells in mice. [2]
References
1 Regulation of CD8(+) T Cells and Antitumor Immunity by Notch Signaling.Front Immunol. 2018 Jan 30;9:101. doi: 10.3389/fimmu.2018.00101. eCollection 2018.
2 A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice. Gut. 2020 Mar 13:gutjnl-2019-320105. doi: 10.1136/gutjnl-2019-320105. Online ahead of print.

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