Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0058)
HIF Name	Vasostatin-1
HIF Synonym(s)	Vasostatin-1, vasostatin-I, chromogranin A-(1-76), CGA1-76
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Fungicide
Description	Vasostatin-1 and chromofungin (chromogranin A) LEAP-2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	Granin (chromogranin or secretogranin) (PF01271 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CMGA_HUMAN
	APD ID	AP02355

Microbe Species (MIC) Regulated by This HIF
Staphylococcus aureus (firmicutes)		MIC01208
Description	The antihypertensive peptide catestatin(Vasostatin-1), which has restricted antimicrobial enzymatic activity against Staphylococcus aureus in vitro.		[2]

References
1	Antimicrobial peptides and the skin immune defense system.J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2	Human Catestatin Alters Gut Microbiota Composition in Mice.Front Microbiol. 2017 Jan 17;7:2151. doi: 10.3389/fmicb.2016.02151. eCollection 2016.

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