Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0067)
HIF Name
Granulocyte colony-stimulating factor
HIF Synonym(s)
colony stimulating factor 3, CSF3, GCSF, CSF3OS, C17orf33, CSF-3
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine; Growth factor
Description CSF3 (Colony Stimulating Factor 3) is a Protein Coding gene. Diseases associated with CSF3 include Neutropenia and Mucositis . [1]
Pfam Granulocyte colony-stimulating factor (PF16647 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Hematopoietic cell lineage (hsa04640 )
IL-17 signaling pathway (hsa04657 )
JAK-STAT signaling pathway (hsa04630 )
Malaria (hsa05144 )
PI3K-Akt signaling pathway (hsa04151 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CSF3_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Enterococcus faecalis (firmicutes) MIC00548
             Description Enterococcus faecalis is associated with the expression csf3. [2]
         Parabacteroides distasonis (CFB bacteria) MIC00949
             Description Parabacteroides distasonis is associated with the expression of G-CSF. [3]
References
1 Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD.Eur Respir J. 2008 Jul;32(1):25-34. doi: 10.1183/09031936.00040307. Epub 2008 Mar 19.
2 Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection. J Infect Dis. 2017 Dec 19;216(12):1644-1654. doi: 10.1093/infdis/jix541.
3 Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol. 2011 Feb;163(2):250-9. doi: 10.1111/j.1365-2249.2010.04286.x. Epub 2010 Nov 19.

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