Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0086)
HIF Name	Dermcidin
HIF Synonym(s)	Dermcidin, DCD-1
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Fungicide; Hydrolase; Protease
Description	Dermcidin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	Dermcidin, antibiotic peptide (PF15291 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	DCD_HUMAN
	APD ID	AP00434

Microbe Species (MIC) Regulated by This HIF
Staphylococcus aureus (firmicutes)		MIC01208
Description	Staphylococcus aureus elimination by lugdunin is additionally achieved by synergistic antimicrobial activity with LL-37 and dermcidin-derived peptides.		[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors.Nat Commun. 2019 Jun 21;10(1):2730. doi: 10.1038/s41467-019-10646-7.

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