Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0089)
HIF Name
Human defensin 6
HIF Synonym(s)
Human Defensin 6, HD-6, HD6
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Defensin; Fungicide
Description human defensin 6 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Defensin propeptide (PF00879 )
Mammalian defensin (PF00323 )
Pathway NOD-like receptor signaling pathway (hsa04621 )
Staphylococcus aureus infection (hsa05150 )
Transcriptional misregulation in cancer (hsa05202 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
DEF6_HUMAN
APD ID
AP00182
Microbe Species (MIC) Regulated by This HIF
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description Salmonella typhimurium counts were 100-fold lower in Peyers patches (P < 0.001) and 10-fold lower in spleens (P < 0.001) of HD6 transgenic mice. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Amyloid formation: functional friend or fearful foe. J Intern Med. 2016 Aug;280(2):139-52. doi: 10.1111/joim.12479. Epub 2016 May 6.

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