Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0103)
HIF Name
Low affinity immunoglobulin gamma Fc region receptor III-B
HIF Synonym(s)
Fc fragment of IgG receptor IIIb, FCGR3B, CD16, FCG3, CD16A, FCGR3, FCGR3A, FCR-10, FCRIII, FCRIIIb
HIF Classification
Fc Receptor (FCR)
Molecular Function
IgG-binding protein; Receptor
Description FcgRIIIb also known as CD16b, is a subtype of Fc Receptor. [1]
Pfam Immunoglobulin domain (PF13895 )
Pathway Fc gamma R-mediated phagocytosis (hsa04666 )
Leishmaniasis (hsa05140 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Osteoclast differentiation (hsa04380 )
Phagosome (hsa04145 )
Staphylococcus aureus infection (hsa05150 )
Systemic lupus erythematosus (hsa05322 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
FCG3B_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description Indeed, in mice, IgG and activating FcgRs are protective against the systemic spread of Citrobacter rodentium, an enteropathic bacteria. [2]
References
1 A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.J Hematol Oncol. 2013 Jan 4;6:1. doi: 10.1186/1756-8722-6-1.
2 Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12.

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