Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0105)
HIF Name
IgG receptor FcRn large subunit p51
HIF Synonym(s)
Fc fragment of IgG receptor and transporter, FCRN, alpha-chain
HIF Classification
Fc Receptor (FCR)
Molecular Function
IgG-binding protein; Receptor
Description FCGRT encodes the alpha-chain component of the neonatal Fc receptor (FcRn). FcRn is critical for the trafficking of endogenous and exogenous IgG molecules and albumin in various tissues. [1]
Pfam Class I Histocompatibility antigen, domains alpha 1 and 2 (PF00129 )
Immunoglobulin C1-set domain (PF07654 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
FCGRN_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description FCGRT encodes the alpha-chain component of Fc receptor (FcRn), mice deficient in FcRn display impaired resistance to the enteric pathogen Citrobacter rodentium. [2]
References
1 Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181.Pharm Res. 2018 Jan 4;35(1):15. doi: 10.1007/s11095-017-2294-0.
2 Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 Jan;577(7791):543-548. doi: 10.1038/s41586-019-1898-4. Epub 2020 Jan 8.

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