Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0117)
HIF Name
HLA class I histocompatibility antigen, alpha chain G
HIF Synonym(s)
HLA-G1, HLA-G, HLAG
HIF Classification
Checkpoint molecule (CM)
Description Human leukocyte antigen G (HLA-G), known as a central protein in providingimmunetolerance to the fetus in pregnant women, is also studied for a possible role in tumor development. Many studies have claimedHLA-G as a newimmune checkpointin cancer. [1]
Pfam Class I Histocompatibility antigen, domains alpha 1 and 2 (PF00129 )
Immunoglobulin C1-set domain (PF07654 )
Pathway Allograft rejection (hsa05330 )
Antigen processing and presentation (hsa04612 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Cellular senescence (hsa04218 )
Endocytosis (hsa04144 )
Epstein-Barr virus infection (hsa05169 )
Graft-versus-host disease (hsa05332 )
Herpes simplex virus 1 infection (hsa05168 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Human cytomegalovirus infection (hsa05163 )
Human immunodeficiency virus 1 infection (hsa05170 )
Human papillomavirus infection (hsa05165 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Phagosome (hsa04145 )
Type I diabetes mellitus (hsa04940 )
Viral carcinogenesis (hsa05203 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
HLAG_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Staphylococcus epidermidis (firmicutes) MIC01214
             Description Staphylococcus epidermidis-induced CD8+ T cells have a distinct cytokine profile and an unconventional HLAG(MHC I) expression restriction. [2]
References
1 HLA-G: A New Immune Checkpoint in Cancer. Int J Mol Sci. 2020 Jun 25;21(12):4528. doi: 10.3390/ijms21124528.
2 Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18.

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