Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0121)
HIF Name	Interleukin-27 receptor
HIF Synonym(s)	interleukin 27 receptor subunit alpha, IL27RA, CRL1, TCCR, WSX1, IL27R, IL-27RA, zcytor1
HIF Classification	Cytokine (Cyt)
Molecular Function	Receptor
Description	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells and dendritic cells.		[1]
Pfam	Fibronectin type III domain (PF00041 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	JAK-STAT signaling pathway (hsa04630 )
	Th17 cell differentiation (hsa04659 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
External Links	Uniprot ID	I27RA_HUMAN

Microbe Species (MIC) Regulated by This HIF
Lactobacillus pentosus (firmicutes)		MIC00728
Description	Cytokine receptor IL-27R was highly expressed during Lactobacillus pentosus KF340 infection.		[2]

References
1	IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.Sci Rep. 2017 May 23;7(1):2255. doi: 10.1038/s41598-017-01828-8.
2	Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells. Immune Netw. 2019 Dec 26;19(6):e39. doi: 10.4110/in.2019.19.e39. eCollection 2019 Dec.

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