Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0156)
HIF Name
Interferon alpha/beta receptor 2
HIF Synonym(s)
interferon alpha and beta receptor subunit 2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45
HIF Classification
Cytokine (Cyt)
Molecular Function
Receptor
Description Interferon-tau (IFNT), a type I interferon, is an antiluteolytic factor secreted by trophoderm during pregnancy.IFNT receptor 2 (IFNAR2) [1]
Pfam Interferon-alpha/beta receptor, fibronectin type III (PF09294 )
Tissue factor (PF01108 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Epstein-Barr virus infection (hsa05169 )
Hepatitis C (hsa05160 )
Herpes simplex virus 1 infection (hsa05168 )
Human papillomavirus infection (hsa05165 )
Influenza A (hsa05164 )
JAK-STAT signaling pathway (hsa04630 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Measles (hsa05162 )
NOD-like receptor signaling pathway (hsa04621 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Necroptosis (hsa04217 )
Osteoclast differentiation (hsa04380 )
PI3K-Akt signaling pathway (hsa04151 )
Pathways in cancer (hsa05200 )
Toll-like receptor signaling pathway (hsa04620 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
INAR2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Lactobacillus casei (firmicutes) MIC00707
             Description Lactobacillus casei could reduce the expression of IFNar2(p<0.05). [2]
References
1 Expression of IFNAR1 and IFNAR2 in cattle placenta during early pregnancy. Reprod Domest Anim. 2018 Apr;53(2):385-392. doi: 10.1111/rda.13118. Epub 2017 Dec 1.
2 The Impact of Lactobacillus casei on the Composition of the Cecal Microbiota and Innate Immune System Is Strain Specific. PLoS One. 2016 May 31;11(5):e0156374. doi: 10.1371/journal.pone.0156374. eCollection 2016.

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