Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0162)
HIF Name
Human liver Expressed Antimicrobial Peptide-2
HIF Synonym(s)
Leap-2, human liver Expressed Antimicrobial Peptide-2, LEAP2
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial
Description LEAP-2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) (PF07359 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
LEAP2_HUMAN
APD ID
AP00794
Microbe Species (MIC) Regulated by This HIF
         Edwardsiella ictaluri (enterobacteria) MIC00517
             Description The expression of LEAP-2 was upregulated in the spleen after challenge with Edwardsiella ictalur. [2]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description Infection with Salmonella enteritidis resulted in up-regulation expression of LEAP-2 mRNA. [3]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 The catfish liver-expressed antimicrobial peptide 2 (LEAP-2) gene is expressed in a wide range of tissues and developmentally regulated.Mol Immunol. 2006 Feb;43(4):367-77. doi: 10.1016/j.molimm.2005.02.014. Epub 2005 Mar 17.
3 Not Avaliable

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.