General Information of HIF (ID: HIFM0190)
HIF Name	Programmed death-ligand 2
HIF Synonym(s)	CD273, PD-L2
HIF Classification	Checkpoint molecule (CM)
Molecular Function	Receptor
Description	PD-L2 plays a major role in preventing overactivation of host immune system and in keeping immunological homeostasis and tolerance by being expressed "at appropriate timing" and on "appropriate cell types".				[1]
Pfam	CD80-like C2-set immunoglobulin domain (PF08205 )
Pathway	Cell adhesion molecules (CAMs) (hsa04514 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	PD1L2_HUMAN

Microbe Species (MIC) Regulated by This HIF
Haemophilus influenzae (gamma-proteobacteria)			MIC00652
Description	Haemophilus influenzae is associated with PD-L2 responses.				[2]
Streptococcus pneumoniae (firmicutes)			MIC01263
Description	PD-L2 was important negative regulators of the adaptive immune response to the polysaccharide capsule of Streptococcus pneumoniae.				[2]

References
1	Microbial biomarkers for immune checkpoint blockade therapy against cancer.J Gastroenterol. 2018 Sep;53(9):999-1005. doi: 10.1007/s00535-018-1492-9. Epub 2018 Jul 12.
2	PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.J Immunol. 2017 Sep 15;199(6):2020-2029. doi: 10.4049/jimmunol.1700555. Epub 2017 Aug 2.

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