General Information of HIF (ID: HIFM0210)
HIF Name	Tryptophan 2,3-dioxygenase
HIF Synonym(s)	TDO, TDO2
HIF Classification	Checkpoint molecule (CM)
Molecular Function	Dioxygenase; Oxidoreductase
Description	The TDO2 is reported to be crucial immunecheckpointmolecules.				[1]
Pfam	Tryptophan 2,3-dioxygenase (PF03301 )
Pathway	Metabolic pathways (hsa01100 )
	Tryptophan metabolism (hsa00380 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	T23O_HUMAN

Microbe Species (MIC) Regulated by This HIF
Staphylococcus aureus (firmicutes)			MIC01208
Description	The HeLa cells expressing recombinant TDO2 were capable of inhibiting the growth of bacteria(Staphylococcus aureus).				[2]

References
1	Non-NF2 mutations have a key effect on inhibitory immune checkpoints and tumor pathogenesis in skull base meningiomas.J Neurooncol. 2019 Aug;144(1):11-20. doi: 10.1007/s11060-019-03198-9. Epub 2019 Jun 8.
2	Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase.Eur J Immunol. 2009 Oct;39(10):2755-64. doi: 10.1002/eji.200939535.

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