Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0227)
HIF Name
Tumor necrosis factor ligand superfamily member 4
HIF Synonym(s)
Glycoprotein Gp34, OX40 ligand, TAX transcriptionally-activated glycoprotein 1, CD252, OX40L
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Cytokine
Description OX40L is expressed on T cells to regulate responses to self-proteins. [1]
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNFL4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Candida albicans (budding yeasts) MIC00317
             Description The abundance of Candida albicans is associated with OX40L. [2]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10672-7. doi: 10.1073/pnas.1402336111. Epub 2014 Jul 7.

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