Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0228)
HIF Name
Tumor necrosis factor ligand superfamily member 9
HIF Synonym(s)
4-1BB ligand, 4-1BBL
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Cytokine
Description 4-1BBL is expressed on T cells to regulate responses to self-proteins. [1]
Pfam TNF(Tumour Necrosis Factor) family (PF00229 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNFL9_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description Akkermansia muciniphila was associated with 4-1BBL. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description The extracellular domain of the 4-1BBL ligand fused with glutathione-S-transferase is expressed in Escherichia coli. [3]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.Sci Transl Med. 2018 Nov 14;10(467):eaat4271. doi: 10.1126/scitranslmed.aat4271.
3 Crystallization and preliminary X-ray crystallographic study of the extracellular domain of the 4-1BB ligand, a member of the TNF family.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jan 1;62(Pt 1):23-5. doi: 10.1107/S1744309105039242. Epub 2005 Dec 16.

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