General Information of HIF (ID: HIFM0229)
HIF Name
Tumor necrosis factor receptor superfamily member 14
HIF Synonym(s)
TR2, HVEA, HVEM, Herpesvirus entry mediator A, CD270
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Host cell receptor for virus entry; Receptor
Description CD270 is reported to be crucial immune modulator. [1]
Pfam TNFR/NGFR cysteine-rich region (PF00020 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Herpes simplex virus 1 infection (hsa05168 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNR14_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description Herpes virus entry mediator (HVEM) (it is also known as TNFRSF14 or CD270) expression by intestinal epithelium provides anti-inflammatory and anti-bacterial protection during Citrobacter rodentium infection correlates well. [2]
References
1 Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2 HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System.Immune Netw. 2014 Apr;14(2):67-72. doi: 10.4110/in.2014.14.2.67. Epub 2014 Apr 21.

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