Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0229)
HIF Name	Tumor necrosis factor receptor superfamily member 14
HIF Synonym(s)	TR2, HVEA, HVEM, Herpesvirus entry mediator A, CD270
HIF Classification	Checkpoint molecule (CM)
Molecular Function	Host cell receptor for virus entry; Receptor
Description	CD270 is reported to be crucial immune modulator.		[1]
Pfam	TNFR/NGFR cysteine-rich region (PF00020 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	Herpes simplex virus 1 infection (hsa05168 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
External Links	Uniprot ID	TNR14_HUMAN

Microbe Species (MIC) Regulated by This HIF
Citrobacter rodentium (enterobacteria)		MIC00366
Description	Herpes virus entry mediator (HVEM) (it is also known as TNFRSF14 or CD270) expression by intestinal epithelium provides anti-inflammatory and anti-bacterial protection during Citrobacter rodentium infection correlates well.		[2]

References
1	Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2	HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System.Immune Netw. 2014 Apr;14(2):67-72. doi: 10.4110/in.2014.14.2.67. Epub 2014 Apr 21.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.