General Information of HIF (ID: HIFM0265)
HIF Name	IL-23 subunit p40
HIF Synonym(s)	interleukin 23p40
HIF Classification	Cytokine (Cyt)
Description	IL-12/IL-23P40 is a 40kDa cytokine that exists in its monomeric form as well as heterodimerizes with a 35kDa subunit to form IL-12/IL-12p70 and heterodimerizes with a 19kDa subunit to form IL-23. IL-12/IL-23P40 can act as a growth factor for activated T and natural killer cells as well as stimulate the production of Interferon gamma.				[1]

Microbe Species (MIC) Regulated by This HIF
Actinobacteria (actinobacteria)			MIC00025
Description	At the phylum level, Actinobacteria is associated with IL-23p40.				[2]

References
1	IL-12/IL-23p40 identified as a downstream target of apremilast in ex vivo models of arthritis.Ther Adv Musculoskelet Dis. 2019 Feb 22;11:1759720X19828669. doi: 10.1177/1759720X19828669. eCollection 2019.
2	Isolation, Diversity, and Antimicrobial and Immunomodulatory Activities of Endophytic Actinobacteria From Tea Cultivars Zijuan and Yunkang-10 (Camellia sinensis var. assamica). Front Microbiol. 2018 Jun 18;9:1304. doi: 10.3389/fmicb.2018.01304. eCollection 2018.

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