General Information of HIF (ID: HIFM0308)
HIF Name
Human neutrophil peptide-4
HIF Synonym(s)
Human Neutrophil Peptide-4, HNP-4, HNP4
HIF Classification
Antimicrobial peptide (AMP)
Description human neutrophil peptide-4 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
External Links
APD ID
AP00180
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description Human neutrophil defensin 4 (HNP4) displays more than 100-fold higher activity against Escherichia coli compared with other defensins. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Human neutrophil peptide-4(HNP4) could be against Staphylococcus aureus. [3]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Oviduct-specific expression of human neutrophil defensin 4 in lentivirally generated transgenic chickens.PLoS One. 2015 May 28;10(5):e0127922. doi: 10.1371/journal.pone.0127922. eCollection 2015.
3 Crystal structures of human alpha-defensins HNP4, HD5, and HD6.Protein Sci. 2006 Dec;15(12):2749-60. doi: 10.1110/ps.062336606. Epub 2006 Nov 6.

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