Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00067)
MIC Name Alistipes putredinis (CFB bacteria)
MIC Synonyms Bacillus putredinis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Rikenellaceae
Genus: Alistipes
Species: Alistipes putredinis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Weakly saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 2549878
Description Alistipes putredinis is a strictly anaerobic, Gram-negative rods, straight or slightly curved, with rounded ends, usually occurring singly or in pairs, non-spore-forming bacterium. It was characterized in the indigenous flora of the human gut. The bacterium is associated with inflammatory bowel disease.
External Links Taxonomy ID
28117
Genome Assembly ID
ASM15446v1
GOLD Organism ID
Go0001935
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Bacteroides putredinis was associated with inflammatory bowel disease. [1]
Host Genetic Factors (HGFs)
          rs571312
             HGF ID HGF2159 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Alistipes putredinis (p-value=0.0125). [2]
Host Immune Factors (HIFs)
          Programmed death-ligand 1
             HIF ID HIFM0189 HIF Info       Class Checkpoint molecule (CM)
             Description Alistipes putredinis is associated with PD-L1. [3]
Environmental Factor(s)
             Disbiome ID
      145
             gutMDisorder ID
      gm0035
References
1 Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat Microbiol. 2018 Mar;3(3):337-346. doi: 10.1038/s41564-017-0089-z. Epub 2018 Jan 8.
2 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
3 Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy.Curr Opin Pharmacol. 2020 Jun 30;54:1-10. doi: 10.1016/j.coph.2020.06.004. Online ahead of print.

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