General Information of MIC (ID: MIC00170)
MIC Name	Bacteroides plebeius (CFB bacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides plebeius
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Negative
Host Relationship	Commensal
Genome Size (bp)	4421324
Description	Bacteroides plebeius is a obligate anaerobic, Gram negative microbe found in the human gut. The microbe is believed to have obtained the gene for degradation of porphyran via horizontal gene transfer. Microbes in the gut are responsible for their production of carbohydrate active enzymes or CAZymes. B. plebeius has also been associated with Celiac disease.
External Links	Taxonomy ID	310297
	Genome Assembly ID	ASM18789v1
	GOLD Organism ID	Go0478177
Disease Relevance
Coeliac disease  [ICD-11: DA95]
Description	The prevalence of Bacteroides plebeius was increased in those with low genetic risk of celiac disease.				[1]
Parkinsonism  [ICD-11: 8A00]
Description	Bacteroides plebeius was associated with parkinsons disease.				[2]

Host Genetic Factors (HGFs)
CYP27B1
HGF ID	HGF2312	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of CYP27B1 was significantly decreased the abundance of Bacteroides plebeius (p-value<0.05).				[3]
CD44
HGF ID	HGF2333	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of CD44 significantly decreased the abundance of Bacteroides plebeiu (p-value<0.05).				[4]

Environmental Factor(s)
Disbiome ID			280
gutMDisorder ID			gm0085

References
1	Influence of environmental and genetic factors linked to celiac disease risk on infant gut colonization by Bacteroides species. Appl Environ Microbiol. 2011 Aug;77(15):5316-23. doi: 10.1128/AEM.00365-11. Epub 2011 Jun 3.
2	Analysis of Gut Microbiota in Patients with Parkinson's Disease. Bull Exp Biol Med. 2017 Apr;162(6):734-737. doi: 10.1007/s10517-017-3700-7. Epub 2017 Apr 20.
3	1,25(OH)(2)D(3) deficiency-induced gut microbial dysbiosis degrades the colonic mucus barrier in Cyp27b1 knockout mouse model.Gut Pathog. 2019 Feb 20;11:8. doi: 10.1186/s13099-019-0291-z. eCollection 2019.
4	CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.

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